Guhindura uburyo abaguzi babona ibintu ku bijyanye no gusaza

Imyumvire y'abaguzi ku bijyanye no gusaza iragenda ihinduka. Dukurikije raporo y'abaguzi yakozwe naUmuguzi MushyanaImari y'Imari Iciriritse, Abanyamerika benshi ntibibanda gusa ku kubaho igihe kirekire ahubwo banashyira imbere ubuzima bwiza.

Ubushakashatsi bwakozwe na McKinsey bwo mu 2024 bwagaragaje ko mu mwaka ushize, 70% by'abaguzi muri Amerika no mu Bwongereza (na 85% mu Bushinwa) baguze ibicuruzwa na serivisi byinshi bishyigikira gusaza no kuramba ugereranije n'imyaka yashize. Iyi mpinduka igaragaza icyifuzo cy'abaguzi cyo kugenzura ubuzima bwabo cyane.

Byongeye kandi,Ikinyamakuru cy'Ubucuruzi bw'Imirire(NBJRaporo y’ubuzima bw’imyaka 2024 igaragaza ko kuva mu 2022, iterambere ry’ibicuruzwa mu cyiciro cy’abasaza bafite ubuzima bwiza ryakomeje kurenga isoko ryagutse ry’inyongeramusaruro. Muri 2023, inganda z’inyongeramusaruro muri rusange ziyongereyeho 4.4%, mu gihe icyiciro cy’abasaza bafite ubuzima bwiza cyageze ku gipimo cy’iterambere cya 5.5%.NBJimishinga igurishainyongeramusaruro nziza zo gusaza—igizwe n’ibice bitandukanye byihariye by’indwara—izarenga miliyari imwe y’amadolari mu 2024 igere kuri miliyari 1.04 z’amadolari mu 2026, bivuze ko izamuka rya 7.7%.
1. Impungenge z'abaguzi ku bibazo by'ubuzima bifitanye isano n'imyaka

AnNBJUbushakashatsi bwakozwe mu 2024 bwagaragaje impungenge z'abaguzi zijyanye no gusaza. Ibibazo by'ingenzi birimo:

Kubura ubushobozi bwo kugenda (28%)
Indwara ya Alzheimer cyangwa indwara yo kwiheba (23%)
Kutabona neza (23%)
Gutakaza ubwigenge (19%)
Ingorane z'ubuzima bw'amarangamutima cyangwa ubwo mu mutwe (19%)
Kwangirika kw'imitsi cyangwa amagufwa (19%)
Gutakaza umusatsi (16%)
Kubura ibitotsi (16%)

Ifoto ikomoka kuri: NBJ

Iyo ukoreshainyongeramusaruro, ubudahangarwa bw'umubiri (35%) bwagaragaye nk'ikibazo gikomeye cy'ubuzima ku bantu bakuze. Ibindi byihutirwaga byari ubuzima bw'amara n'igogora (28%), ubuzima bwo gusinzira (23%), umusatsi, uruhu, n'inzara (22%), ubuzima bw'imitsi n'ingingo (21%), ubuzima bw'umutima (19%), n'imibereho myiza y'amarangamutima (19%).

Ifoto ikomoka kuri: NBJ

2. Ibintu bitanu by'ingenzi birwanya gusaza

1. Ergothioneine

Ergothioneine ni aside amine isanzwe yavumbuwe mu 1909 na Charles Tanret ubwo yigaga ku bihumyo bya ergot. Ingano yayo yihariye ya thiol na thione tautomerism kuri pH y'umubiri iha ubushobozi budasanzwe bwo kurwanya udukoko. Dukurikije amakuru ya Bloomage Biotech, ergothioneine muri Bioyouth™-EGT igaragaza imikorere ya DPPH yo gukata udukoko twinshi inshuro 14 z'ubunini bwa glutathione n'inshuro 30 z'ubunini bwa coenzyme Q10.

Ibyiza:

Uruhu:Ergothioneine irinda ububyimbirwe buterwa n'imiraba ya UV, ikarinda kwangirika kwa ADN, kandi igateza imbere imikorere ya collagen mu gihe ikagabanya kwangirika kwa collagen bifitanye isano na UV.
Ubwonko:Ergothioneine ishyigikira imikorere y'ubwonko, nk'uko bigaragazwa n'ubushakashatsi bwakorewe ku buvuzi bwerekana ko ubwenge bwarushijeho kuba bwiza nyuma y'ibyumweru 12 byongewemo ergothioneine ikomoka ku bihumyo.
Gusinzira:Inyura mu muyoboro w’amaraso n’ubwonko, igabanya ikorwa rya peroxynitrite, kandi ikagabanya stress, bigatuma umuntu asinzira neza.

2. Spermidine

Spermidine, imwe mu bigize umuryango wa polyamine, iboneka cyane mu binyabuzima nka bagiteri, ibihumyo, ibimera, n'inyamaswa. Inkomoko rusange y'ibiribwa irimo ingano, soya, n'ibihumyo byitwa king oyster. Igipimo cya Spermidine kigabanuka uko imyaka igenda ishira, kandi ingaruka zacyo zo kurwanya gusaza ziterwa n'uburyo bwo gutera autophagy, kurwanya ububyimbirwe, no kugenzura uburyo lipide zikoreshwa mu gutunganya umubiri.

Uburyo:

Autophagy:Spermidine iteza imbere ibikorwa byo kongera gukoresha utunyangingo, ikemura indwara ziterwa no gusaza ziterwa n'ubumuga bw'umubiri.
Irwanya ububyimbirwe: Igabanya cytokines zitera ububyimbirwe mu gihe yongera ibintu birwanya ububyimbirwe.
Ihinduka ry'ibinure mu mubiri:Spermidine igira uruhare rwiza mu ikorwa ry’ibinure n’ububiko, ishyigikira uburyo uturemangingo duto duto duto duto kandi tugakomeza kubaho.

3. Pirroloquinoline Quinone (PQQ)

PQQ, coenzyme ya quinone ishongeshwa n'amazi, ni ingenzi cyane mu mikorere ya mitochondrial. Irinda kwangirika kwa mitochondrial guterwa n'ingufu za oxidative, iteza imbere biogenesis ya mitochondrial, kandi yongera umusaruro w'imitsi (NGF). Ubushakashatsi bwa muganga bwerekana ko ifite akamaro mu kunoza imikorere y'ubwonko n'inzira y'amaraso mu gace k'abantu bageze mu za bukuru.

4. Fosfatidylserine (PS)

PS ni fosfolipide ikora nk'iy'amoniki mu ngirabuzimafatizo za eukaryotic, ikaba ari ingenzi mu bikorwa nko gukora enzymes, apoptosis y'uturemangingo, no gukora kwa synaptic. PS ikomoka ku masoko nka soya, ibinyabuzima byo mu mazi, n'ibihwagari, ishyigikira sisitemu z'imitsi, harimo acetylcholine na dopamine, bifitanye isano n'ubuzima bw'ubwenge.

Porogaramu:Gutanga imiti igabanya ubukana bwa PS byagize uruhare mu kunoza indwara nka Alzheimer, Parkinson, n'ihungabana, kandi bifasha abantu bafite ADHD na autism spectrum disorders.

5. Urolithine A(UA)

UA, ikinyabutabire cya ellagitannins kiboneka mu biribwa nk'amakomamanga n'imbuto z'indobanure, cyagaragaye mu 2005. Ubushakashatsi bwashyizwe ahagaragara muriUbuvuzi bw'ibidukikije(2016) yagaragaje ko UA iteza imbere mitophagy, yongera igihe cyo kubaho cy’udusimba two mu bwoko bwa nematode ku kigero cya 45%. Ikora inzira za mitophagy za mitochondria, igakuraho mitochondria yangiritse kandi igakemura ibibazo bijyanye n’izabukuru mu mitsi, umutima, ubudahangarwa bw’umubiri, n’ubuzima bw’uruhu.

Inzira ya mitophagy yashyizweho na UA/Ishusho y'isoko 1

Umwanzuro

Uko abaguzi barushaho gushyira imbere ubuzima n'ubuzima burambye, ni ko icyifuzo cy'ibintu bishya birwanya gusaza n'inyongeramusaruro gikomeje kwiyongera. Ibintu by'ingenzi nka ergothioneine, spermidine, PQQ, PS, na UA biri gutegura inzira y'ibisubizo byihariye ku bibazo bifitanye isano n'izabukuru. Ibi bintu bishyigikiwe na siyansi bigaragaza ko inganda zishishikajwe no gushyigikira gusaza ku buzima kandi ku buryo burambye.