Nkabantu baje, kugabanuka mumikorere yubwonko biba bigaragara. Mu bantu bafite imyaka 20-49, benshi batangira kubona kugabanuka mu mirimo yo kumenya iyo bahuye no kwibuka cyangwa kwibagirwa. Kuri abo bafite imyaka 50-59, kumenya kugabanuka kwubwenge akenshi biza iyo batangiye kubona igitonyanga kigaragara mu mutwe.
Mugihe ushakisha inzira zo kongera imikorere yubwonko, imyaka itandukanye yibanda kubintu bitandukanye. Abantu bafite imyaka 20-29 bakunda kwibanda ku kunoza ibitotsi kugirango bahindure imikorere yo mu bwonko (44.7%), mu gihe abantu bafite imyaka 30-39 bashishikajwe no kugabanya umunaniro (47.5%). Kuri abo bafite imyaka 40-59, kunoza ibitekerezo bifatwa nkurufunguzo rwo kuzamura imikorere yubwonko (imyaka 40-49: 44%, imyaka 50-59: 43.4%).
Ibikoresho bizwi ku isoko ryubuzima bwubuyapani
Dukurikije uko isi igenda ikoresha ubuzima bwiza, isoko ry'ibiribwa ry'Ubuyapani gushimangira cyane gukemura ibibazo byihariye byubuzima, bifite ubuzima bwubwonko kuba intera ikomeye. Kugeza ku ya 11 Ukuboza 2024, Ubuyapani bwari bwanditse ibiryo 1.012 bikora (hakurikijwe amakuru yemewe), muri byo 79 byari bifitanye isano n'ubuzima bw'ubwonko. Muri ibyo, Gaba yari afite intego yakoreshejwe, ikurikirwa nalutein/zeaxanthin, Ginkgo yamababi ya ginkgo (Flavonoides, tepernoide),Dha, Bifidobacterium mcc1274, Igishushanyo cya Portulaca Oleacea, Patlitaxel, Imidazolidine iragaba,Pqq, na ergothiteinene.
1. Gaba
Gaba (γ-aminobutyric acide) ni acide itari Proteinogenic Amino yamenyekanye mbere n'ibisonga na bagenzi be mu biti by ibirayi by'igituba mu 1949. Mu 1950, Robets et. yerekanye Gaba mubwonko bwa Mammaliyani, bwakozwe binyuze mu buryo budasubirwaho α-Guhakana Karixy ya Glutamate cyangwa umunyu, cataliz na glutamate dedboxylase.
Gaba ni neurotrantmitter ikomeye yasanze cyane muri sisitemu yimbarire ya Mammaliyani. Imikorere nyamukuru ni ukugabanya umunezero wa Neuronal ubuza kohereza ibimenyetso bishya. Mu bwonko, impirimbanyi hagati yo kubuza NeuroRtrermission yashinzwe na Gaba no kumvikana ku buryo bushimishije bwo kubungabunga umutekano w'ikigari n'imikorere isanzwe ya selile n'imikorere isanzwe.
Ubushakashatsi bwerekana ko Gaba ashobora kubuza impinduka za neuroEgenenes no kunoza imikorere no kumenya ibikorwa. Ubushakashatsi bwinyamaswa bwerekana ko Gaba atezimbere ububiko bwigihe cyigihe cyimbeba hamwe no kugabanuka kandi biteza imbere ikwirakwizwa rya neuroendocrine pc-selile. Mu bigeragezo by'amavuriro, Gaba yagaragaye ko muri Serum yakomokaga mu bwonko (BDNF) kandi agabanya ibyago byo gutwarwa no guhambira Alzheimer na Alzheimer mu bagore bageze mu za bukuru.
Byongeye kandi, Gaba afite ingaruka nziza mumyumvire, guhangayika, umunaniro, no gusinzira. Ubushakashatsi bwerekana ko uruvange rwa Gaba na L-Theline rushobora kugabanya ibitotsi, byongera gusiga ibitotsi, no kuzamura imvugo ya Gaba na GlunAmate Glun1 reseptor Subpor.
2. Lutein / zeaxanthin
LuteinEse carotenoid ya ogisijeni igizwe n'ibisigazwa umunani bya ISoprene, polyene idahujwe ikubiyemo ubumwe bw'ibiriba icyenda, bikurura kandi bihuza urumuri ku burebure bumwe, butanga imiterere yihariye y'amabara.Zeaxanthinni isomer ya lutein, itandukanye mumwanya wubumwe bwimpeta.
Lutein na zeaxanthinni pigment yibanze muri retina. Lutein aboneka cyane muri retina ya periferique, mugihe Zeaxanthin yibanze kuri macula yo hagati. Ingaruka zo kurindalutein na zeaxanthinErega amaso arimo kunoza icyerekezo, gukumira imyaka ijyanye no kwangirika mu myaka (AMD), cataract, glaucoma, no gukumira igikona mu mpinja.
Muri 2017, abashakashatsi baturutse muri kaminuza ya Jeworujiya basanzelutein na zeaxanthinIngaruka nziza ubuzima bwubwonko mubakuze bakuze. Ubushakashatsi bwerekanye ko abitabiriye urwego rwo hejuru rwalutein na zeaxanthinyerekanye ibikorwa byo hasi ubwo bwonko mugihe ukora ijambo ryibutsa imirimo, asobanura imikorere yo murwego rwo hejuru.
Byongeye kandi, ubushakashatsi bwatangaje ko Lutemuke 2020, inyongera ya Lushino, yongereye cyane urwego rwa BDNF (ruharanira inyungu zo gukura no gutandukanya imikurire ya neuro. Kandi bifitanye isano na neuron, kandi bifitanye isano no kwigira, kwibuka, n'imikorere, n'imikorere y'ubuvuzi.
(Fomulaire yimiterere ya lutein na zeaxanthin)
3. Gukuramo ibibabi bya Ginkgo (Flavonoides, Tegenonide)
Ginkgo Biloba, amoko yonyine yo kurokoka mu muryango wa Ginkgo, akunze kwita "ibisigazwa bizima." Amababi n'imbuto byacyo bikoreshwa mubushakashatsi bwa farumasi kandi ni kimwe mu miti isanzwe ikoreshwa kwisi yose. Ibikorwa bikora mu gukuramo ibibabi bya Ginkgo cyane cyane byerekanaga cyane na tegenoide, bifite imitungo nko kugabanya ijisho, kugabanya ibitekerezo, no gutanga uburinzi bwangiritse.
Imiterere yumuryango wisi ku isi ku bimera bivura isobanura ko bisanzweGinkgoInkuta z'ibabi zigomba kuba zirimo 22-27% Glycosides na 5-7%, hamwe na acide ya ginkgolique munsi ya 5 mg / kg. Mu Buyapani, Ishyirahamwe ry'ibiribwa n'imirire n'imirire ryashyizeho ibipimo byiza by'ibabi rya Ginkgo Ibisohoka, bisaba glycoside kubirimo byibuze 24% n'ibirimo byibura 6%, hamwe na acide ya Ginkgolic yabitswe munsi ya 5 ppm. Abasabwa buri munsi kubakuze bari hagati ya 60 na 240 mg.
Ubushakashatsi bwerekanye ko kunywa igihe kirekire byo gukuramo ibibabi bya ginkgo, ugereranije no mu mirimo imwe n'imwe yo kumenya, harimo no kwibuka neza kandi ubushobozi bw'urubanza. Byongeye kandi, gukuramo Ginkgo byamenyeshejwe kuzamura amaraso n'ibikorwa.
4. Dha
Dha. Nibyiza mubice byo mu nyanja n'ibicuruzwa byabo, cyane cyane amafi yibinure, atanga 0.68-1.3 garama ya Dha kuri garama 100. Ibiryo bishingiye ku nyamaswa nk'amagi n'inyama birimo dha. Byongeye kandi, amata yonsa yabantu hamwe nandi mata yinyamabere nayo arimo dha. Ubushakashatsi ku bagore barenga 2.400 mu bushakashatsi 65 babonye ko impuzandengo yo kwibanda kuri DHA mu mata yonsa ari 0,10% kugeza kuri 1.40, hamwe n'abaturage bo ku nkombe z'ibanze kuri DHA.
Dha ifitanye isano niterambere ryubwonko, imikorere, nindwara. Ubushakashatsi bwagutse bwerekana koDhaIrashobora kuzamura NeuroRtrensitions, gukura kwa Neuronal, plastike ya synaptique, no kurekura neurot. Isesengura ryibigeragezo 15 byateganijwe byerekanwe ko impuzandengo ya buri munsi ya MG ya DHA ya Dha igaragara cyane mu bice bifatika (imyaka 18-90) hamwe nabafite ubumuga bwo kumenya neza.
Uburyo bwa Dha ibikorwa birimo: 1) Kugarura karujiya n-3 / n-6 putiya; 2) kubuza neuroinfmverm ijyanye na microgliation ya M1 microglial of selile; 3) Guhagarika A1 Astrocyte Phenotype mugumanya ibimenyetso bya A1 nka C3 na S100B; 4) kubuza neza inzira ya probdnf / p75 yamaganye nta guhindura ibintu byatunganijwe byubwonko-bifitanye isano na kinase b ikimenyetso; na 5) Guteza imbere kubaho kwa Neuronal mu kubaho no kongera urwego rwa Fosksidylserserserse, rworohereza kuri Proteine Kinase B (AKT) yo guhinduranya no gukora.
5. Bifidobacterium mcc1274
Isote, akenshi ivugwa nk "ubwonko bwa kabiri," bwerekanwe kugira imikoranire ikomeye n'ubwonko. Isoni, nkingingo ifite ingendo yigenga, irashobora gukora yigenga nta nyigisho itaziguye. Ariko, isano iri hagati yubwonko nubwonko ikomeza muburyo bwa houtogo yigenga, ibimenyetso bya dormonal, na Cytokine, bikora ibizwi nka "but-ubwonko."
Ubushakashatsi bwerekanye ko bacteria yatangaje ko bacteria zigira uruhare mu kwegeranya β-amyloide poroteyine, ikimenyetso cy'ingenzi mu ndwara ya Alzheimer. Ugereranije nubugenzuzi bwubuzima bwiza, abarwayi ba Alzheimer bagabanije gut microbiota itandukanye, bagabanuka muri bifidobacterium nyinshi.
Mubyigisho byabantu bitabiriye kugiti cyabo bafite ubumuga bwo kwitonda (MCI), gukoresha Bifidobacterium Mcc1274 Kunoza cyane imikorere yubuzima mu kizamini cyibuka kuri Rivermead (RBANS). Amanota ahantu hagaragara ko kwibuka byihuse, ubushobozi bwagaragara - ubushobozi bwo gutunganya, gutunganya bigoye, no gutinda byatejwe imbere nabo byimazeyo.
Igihe cyo kohereza: Jan-07-2025